اثر توأم تمرین استقامتی و عصاره آبی زیره کوهی بر چربی‌های پلاسما در موش‌های سوری نر هیپرکلسترولمیک

Background and Objectives: The effect of endurance training on lipid profile and cardiovascular endurance in normal rat after Bunium Persicum Extract (BPE) administration has been previously investigated. In the present study, the effect of co-administration of endurance training and persicum extract on plasma lipid and lipoproteins in hypercholesterolemic male mice was examined. Material and Methods: In this experimental study, 60 male mice were, randomly, divided into 4 groups: Vehicle, Endurance Training (ET), Bunium Persicum Extract Administer (BPEA) and ET-BPEA group. The Exercise protocol was performed at a speed of 18 m/min, 40 min/day, 5 day/week for 6-weeks. The Bunium Persicum Extract was also administered in the same period and the desired dose (0.8 mg) was reconstituted in 0.4 ml of distilled water. The amount of Triglyceride (TG), Total Cholesterol (TC), HDL-c, LDL-c and Body Weight were registered at the beginning and also at the end of the 6 weeks. Data were analysed using one-way ANOVA method. Results: The results indicated that the 6-week endurance training accompanied by Bunium Persicum aquous extract administration reduced TC (pretest 297.7±37.08, post test 146.1±30.8, p=0.019) and LDL-c concentrations (pretest 151.8±14.4, post test 0.12±8.7, p=0.001). On the other hand, Bunium Persicum aquous extract administration increased HDL-c concentration significantly (pretest 75.9±12.1, post test 119.9±17.9, p=0.003). Furthermore, the results showed that body weight changes were not significant. Conclusion: These results suggest that co-administration of BPE and ET could significantly affect plasma lipid and lipoproteins. Therfore performing such program maybe useful for preventing cardiovascular diseases. Key words: Endurance Training, BPE, Plasma Lipoproteins, Lipids, Mice   Funding: This research was funded by Kerman University of Medical Sciences, and Shahid Bahonar University of Kerman. Conflict of interest: None declared. gte vml 1]> Ethical Approval: The Ethical Committee of Kerman University of Medical Sciences approved the study. (Ethical code 85-86 KA)